808-Nm Near-Infrared Laser Photobiomodulation versus Switched-Off Laser Placebo in Major Aphthae Management: A Randomized Double-Blind Controlled Trial

Background: the aphtha is one of most common oral mucosal ulcerations and presents as a painful punched-out sore. Systemic topical medications are used to reduce inflammation pain support natural period remission. Alternative treatment modalities have been requested relieve improve its healing. In this regard, photobiomodulation, which manipulation cells’ metabolism through an energy transfer by light sources non-ablative or thermal intensity, could management. The predictor variable our research was photobiomodulation higher power irradiated handpiece with flat-top beam profile. primary end point complete healing aphtha, defined time from irradiation recovery. secondary relief, evaluated daily visual analogue scale (VAS), 24 48 h after. Methods: randomized, double-blind, controlled trial conducted according CONSORT guideline. Irradiation performed 808-nm diode laser handpiece, 1 W, W/cm2, 60 J, J/cm2 for s on spot-size area cm2. Time evaluation VAS were evaluated. Results: between January, 2020 March, 2021, 126 patients screened study at Department Surgical Diagnostic Sciences, University Genoa, Italy. Sixty randomly assigned (30 in group 30 placebo group). Patients experienced average 8.13 days ± 1.69 (min 5–max 10 days), while extended 30.76 4.63 25–max 42 days). therapy statistically significant reduction discomfort after (p < 0.05); 0.05) compared Conclusions: parameters modality proposed accelerates recovery reduces treated placebo.